You have probably experienced this feeling before: after two hours of running or three hours in the saddle, your legs feel like lead, your mind becomes foggy, and one thought dominates: “How many kilometers are left?” This is what is known as hitting “the wall” or “bonking.”
To avoid this “running out of fuel,” knowledgeable endurance athletes—marathon runners, trail runners, and cyclists—use energy gels. But among the options, one family stands out: antioxidant gels. More than just a concentrated source of sugar, they promise to protect your muscles and improve your recovery.
Is it just a marketing claim or a genuine ally? How can you use it without ending up with stomach cramps? In this guide, we will break down what science and experience tell us.
The basics: what is an energy gel?
Our body uses a mixture of fat and sugar to produce energy and fuel the muscles. This sugar is stored in our muscles and liver as glycogen.
The problem is that this sugar tank has limited capacity. After about 90 minutes of intense exercise, it is almost empty. If you do not refuel, it is an empty tank: your muscles can no longer maintain the intensity.
An energy gel is a concentrated dose of sugar in 30 to 40 ml of liquid. Its purpose is simple:
- Maintain our blood sugar levels (the amount of sugar in the blood).
- Avoid depleting our reserves too quickly so we can keep going longer.
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Fuel our brains to maintain your motivation and concentration.
The “antioxidant” function: why is it so important?
This is where it gets interesting. When you run or cycle, your muscles consume enormous amounts of oxygen—up to 200 times more than at rest in your active muscle fibers. This massive consumption creates waste products called free radicals.
The rust analogy
To understand it properly, imagine that intense exercise makes your cells “rust” from the inside. This is oxidative stress. In small doses, this rust is useful because it tells your body: “Hey, we’re working hard—we need to get stronger!” But during a marathon or a long trail run, this rust becomes too widespread. It attacks the membranes of your muscles, creates micro-tears, and accelerates fatigue.

The role of the antioxidant gel
The antioxidant gel contains molecules (vitamins C and E, zinc, polyphenols) that act as anti-rust agents. They neutralize free radicals before they cause too much damage.
However, be careful: Science tells us not to take too many chemical antioxidants (in highly dosed capsules) every day during training, as this can prevent your body from adapting. But on the day of a competition or a hard workout, a moderate intake through your gels is an excellent strategy for protecting your muscle fibers.
Absorption: how does sugar reach your muscles?
Not all sugars are equal. If you read the label of a good antioxidant gel, you will often see a blend of glucose (or maltodextrin) and fructose.
The “doors” of your intestine
Imagine that your intestine is a room with two entrance doors:
- The glucose door (SGLT1): It is narrow. It lets only 60g of sugar per hour through. If you eat more, the rest remains in your stomach and makes you feel sick.
- The fructose door (GLUT5): This is a back door. It lets an additional 30 to 50g per hour into the bloodstream and therefore the muscles.
The best gels use a 1:0.8 ratio (1 dose of glucose to 0.8 dose of fructose). This blend allows you to absorb up to 90g or even 100g of sugar per hour without bottlenecks at the entrance. This is the key to performing over very long distances without digestive problems.
Sport-specific strategy: when should you take your first gel?
You don't fuel the same way for a 10K as you do for an ultratrail. Here is the battle plan recommended by the experts:
The Marathon (42.195km)
The marathon is the sport famous for the “wall.” Your reserves run out around the 30th kilometer if you do nothing.
- The first gel: Between the 45ème and the 60me minute.
- After that: One gel every 5 to 7km (that is, every 30 to 45 minutes).
- Tip: Take your gels just before an aid station so you can drink water immediately afterward.
Trail and Ultra-Trail
Here, the intensity varies with the elevation gain.
- Uphill: Blood flows to your thighs, and your stomach receives less blood. Avoid very thick gels in the middle of a steep climb.
- On descents or flat sections: Take advantage of it! Experts often recommend taking a gel just before a long descent to stay alert (descending requires a great deal of concentration to avoid falling).
- Alternate: On a trail lasting more than 5 hours, alternate between sweet gels, solid bars, and even savory foods to avoid becoming disgusted by the sweet taste.
Cycling
Cycling makes it easier to eat because your body does not experience the impact of running, and breathing is easier.
- The first gel: At around 60 to 90 minutes.
- After that: Every 45 minutes.
- In addition: The gel is perfect for intense moments (climbs, attacks). During easier moments, favor solid foods (banana, energy bar).
Triathlon
The critical moment is the transition.
- At the end of the bike leg: Take an antioxidant gel 15 minutes before getting off the bike. This prepares your body for the impact of running.
- Running: One gel every 30 to 40 minutes to go the distance.
An athlete’s nightmare: gastric problems
Have you ever had cramps or had to make an emergency stop behind a bush? It is not necessarily the gel’s fault, but often the way you took it.
The mistake of not drinking enough water
A gel is a more or less thick liquid. If it reaches your intestine without water, your body will “pump” water from your blood into your intestine to dilute it. Result: you become dehydrated and your intestine swells, causing pain.
The solution: Always drink approximately 200ml of water (about two big sips) with each gel. Even better, if you use resealable gels like those from Mulebar, take them in 3 servings with a small sip of water each time. The sugar intake is more gradual and this prevents the “roller-coaster effect”
Intensity that is too high
If you are running at 90% of your maximum heart rate, your digestive system is shut down. The blood is in your muscles, not your stomach. If you swallow a gel at that point, it will sit in your stomach. Wait for a calmer moment or slow down slightly to take your gel.
Gut training: the secret key
We train our heart, lungs, legs... but we often forget to train our stomach! This is called Gut Training.
Science has proven that if you train your gut to eat during exercise, it will produce more “doors” (sugar transporters) to absorb energy faster.
Simple 8- to 10-week protocol:
- Month 1: During your long outings, take one gel per hour, even if you do not feel the need for it.
- Month 2: Increase the dose. Try moving up to 1.5 or 2 gels per hour (approximately 40 to 60g of carbohydrates).
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Last few weeks: Test the exact gels you will use on race day to make sure that the taste and texture still suit you after several hours of effort.
A closer look at Mulebar antioxidant gels
Mulebar antioxidant gels are unique on the market thanks to their fluid, 100% natural composition, with no preservatives or other additives (always check the ingredients before buying a gel), and especially thanks to their resealable, reusable packaging, which makes all the difference, particularly for those who find that consuming a whole gel at once is far too much... and they are right!
The homemade alternative: honey, maple syrup, and agave syrup
If you prefer to make your own homemade gels, these three ingredients are perfect.
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Honey: It is the ultimate natural antioxidant. It contains enzymes that aid digestion and polyphenols that protect your cells. In addition, its natural blend of sugars is very close to the ideal glucose/fructose ratio.
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Maple Syrup: Very popular among Canadian trail runners, it provides potassium and zinc. Its taste is very pleasant.
- Agave syrup: relatively neutral in taste, but with a very low glycemic index, so it releases energy slowly.
Mix honey (or maple syrup), a pinch of salt, a little lemon juice, and a little water for the right texture. All that remains is to put it in a small silicone flask.
The 5 fatal mistakes to avoid on race day
- Waiting until you feel hungry or thirsty: When the signal reaches the brain, your reserves are already critically low. Follow your watch, not your sensations.
- Taking a gel with an isotonic drink: Too much sugar at once! If your bottle already contains sugar, take your gel with plain water only.
- Taking ibuprofen for the pain: A serious mistake. Anti-inflammatory drugs increase intestinal permeability. Combined with the gel, this can cause severe digestive bleeding.
- Changing brands on race morning: "Oh, my boyfriend recommended this one; it's great!" Never do that. Your stomach does not know this product, and it could reject it violently.
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Forgetting the salt: If you only consume sugar, you risk hyponatremia (low sodium). Check that your gels contain sodium (salt), especially if it is hot; you will avoid or delay the onset of cramps.
The antioxidant gel, your performance ally
The antioxidant energy gel is not a magic potion, but it is a precision tool. By providing sugar for your muscles and protectors for your cells, it helps you maintain your effort for longer and avoid finishing "destroyed" after crossing the finish line.
The secret to success? Choose a quality gel (a glucose/fructose blend), always drink water with it, and above all, train your gut as much as your legs during your preparation. Good luck!
